Solid-phase synthesis of tertiary methylamines via reductive alkylation-fragmentation using a hydroxylamine linker

被引：18

作者：

Blaney, P

Grigg, R ^{[1
]}

Rankovic, Z

Thoroughgood, M

机构：

[1] Univ Leeds, MIDAS Ctr, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Organon Labs Ltd, Dept Med Chem, Newhouse ML1 5SH, Scotland

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 34期

关键词：

solid-phase synthesis; tertiary methylamines; traceless hydroxylamine linker;

D O I：

10.1016/S0040-4039(00)01103-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid-phase synthesis of tertiary methylamines via reductive alkylation-fragmentation employing a hydroxylamine linker is described. The hydroxylamine linker is traceless, robust and versatile, allowing strong organometallic reagents to be used in the synthesis of diverse tertiary methylamines. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6635 / 6638

页数：4

共 16 条

[1] Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures [J].