IL-17 signaling in host defense and inflammatory diseases

被引：90

作者：

Qian, Youcun ^{[2
,3
]}

Kang, Zizhen ^{[1
]}

Liu, Caini ^{[1
]}

Li, Xiaoxia ^{[1
]}

机构：

[1] Cleveland Clin, Lerner Res Inst, Dept Immunol, Cleveland, OH 44915 USA

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200025, Peoples R China

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2010年 / 7卷 / 05期

基金：

中国国家自然科学基金;

关键词：

inflammation; interleukin-17; signaling; CENTRAL-NERVOUS-SYSTEM; INTERLEUKIN-17; RECEPTOR; DIFFERENTIAL REGULATION; ADAPTER PROTEIN; FAMILY-MEMBERS; TUMOR-GROWTH; TH17; CELLS; CYTOKINE; ACT1; REQUIREMENT;

D O I：

10.1038/cmi.2010.27

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Interleukin (IL)-17, the signature cytokine secreted by T helper (Th) 17 cells, plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune inflammatory diseases. Here we review the recent advances in IL-17-mediated functions with emphasis on the studies of IL-17-mediated signal transduction, providing perspective on potential drug targets for the treatment of autoimmune inflammatory diseases. Cellular & Molecular Immunology (2010) 7, 328-333; doi:10.1038/cmi.2010.27; published online 31 May 2010

引用

收藏

页码：328 / 333

页数：6

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