IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation

被引：45

作者：

Awasthi, Amit ^{[1
]}

Kuchroo, Vijay K. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 06期

关键词：

T-CELLS; DISEASE; MICE;

D O I：

10.1038/ni0609-568

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper type 1 cells (T(H)1 cells) serve a dominant function in T cell-mediated colitis. New work reports that interleukin 17A, an effector cytokine required for the development of autoimmune tissue inflammation, directly inhibits T(H)1 development by suppressing the expression of key T(H)1-associated genes and therefore regulates T(H)1 cell-mediated colitis.

引用

页码：568 / 570

页数：4

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