Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space

被引：28

作者：

Schmolka, Nina ^{[1
]}

Wencker, Melanie ^{[2
,3
]}

Hayday, Adrian C. ^{[2
,4
]}

Silva-Santos, Bruno ^{[1
,5
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Med Mol, P-1649028 Lisbon, Portugal

[2] Canc Res UK, London Res Inst, London, England

[3] Inserm U1111, CIRI, Immun & Cytotox Lymphocytes, Lyon, France

[4] Kings Coll London, Peter Gorer Dept Immunobiol, London WC2R 2LS, England

[5] Gulbenkian Inst Sci, Oeiras, Portugal

来源：

SEMINARS IN IMMUNOLOGY | 2015年 / 27卷 / 01期

基金：

欧洲研究理事会; 英国惠康基金;

关键词：

gamma delta T cells; T cell development; Pro-inflammatory cytokines; LYMPHOID STRESS-SURVEILLANCE; ALPHA-BETA; IFN-GAMMA; INTERFERON-GAMMA; CUTTING EDGE; TH17; CELLS; INTERLEUKIN-17; PRODUCTION; PROINFLAMMATORY IL-17(+); LINEAGE COMMITMENT; IMMUNE-SYSTEM;

D O I：

10.1016/j.smim.2015.01.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

gamma delta T cells are major providers of the pro-inflammatory cytokines interferon-gamma (IFN gamma) and interleukin-17 (IL-17)in protective or pathogenic immune responses. Notably, murine gamma delta T cells commit to either IFN gamma or IL-17 production during development in the thymus, before any subsequent activation in the periphery. Here we discuss the molecular networks that underlie thymic gamma delta T cell differentiation, as well as the mechanisms that sustain or modify their functional properties in the periphery. We concentrate on recent findings on lymphoid and tissue-resident gamma delta T cell subpopulations, with an emphasis on genome-wide studies and their added value to elucidate the regulation of gamma delta T cell differentiation at the transcriptional and epigenetic (chromatin) levels. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：19 / 25

页数：7

共 92 条

[1] Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice [J].