Cutting Edge: Spontaneous Development of IL-17-Producing γδ T Cells in the Thymus Occurs via a TGF-β1-Dependent Mechanism

被引：112

作者：

Do, Jeong-su ^{[1
]}

Fink, Pamela J. ^{[3
]}

Li, Lily ^{[1
,2
]}

Spolski, Rosanne ^{[4
,5
]}

Robinson, Janet ^{[6
]}

Leonard, Warren J. ^{[4
,5
]}

Letterio, John J. ^{[6
]}

Min, Booki ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Immunol, Lerner Res Inst, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Cleveland Clin, Lerner Coll Med, Cleveland, OH 44195 USA

[3] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[4] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

[5] NHLBI, Ctr Immunol, NIH, Bethesda, MD 20892 USA

[6] Case Western Reserve Univ, Div Pediat Hematol Oncol, Dept Pediat, Cleveland, OH 44106 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 184卷 / 04期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR-BETA; INTERFERON-GAMMA; ADULT THYMUS; TGF-BETA; INFLAMMATION; EXPRESSION; IL-17; DIFFERENTIATION; HETEROGENEITY; NEUTROPHILS;

D O I：

10.4049/jimmunol.0903539

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In naive animals, gamma delta T cells are innate sources of IL-17, a potent proinflammatory cytokine mediating bacterial clearance as well as autoimmunity. However, mechanisms underlying the generation of these cells in vivo remain unclear. In this study, we show that TGF-beta 1 plays a key role in the generation of IL-17(+) gamma delta T cells and that it mainly occurs in the thymus particularly during the postnatal period. Interestingly, IL-17(+) gamma delta TCR+ thymocytes were mainly CD44(high)CD25(low) cells, which seem to derive from double-negative 4 gamma delta TCR+ cells that acquired CD44 and IL-17 expression. Our findings identify a novel developmental pathway during which IL-17-competent gamma delta T cells arise in the thymus by a TGF-beta 1-dependent mechanism. The Journal of Immunology, 2010, 184: 1675-1679.

引用

页码：1675 / 1679

页数：5

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