The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5

被引：25

作者：

Hattori, Y ^{[1
]}

Yamasaki, M ^{[1
]}

Itoh, N ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT BIOCHEM GENET,KYOTO 60601,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1996年 / 1306卷 / 01期

关键词：

FGF; splicing; mRNA; growth factor;

D O I：

10.1016/0167-4781(19)60001-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We isolated rat FGF-5 cDNA and its variant from the embryo. The FGF-5 cDNA encodes a protein of 266 amino acid residues. The variant cDNA encodes a protein of 121 amino acid residues, the N-terminal 117-amino acid sequence of which is identical to that of FGF-5. Thus, the variant cDNA encodes a novel truncated form of FGF-5. The rat FGF-5 gene consists of three exons (exons 1-3). The variant cDNA lacks the nucleotide sequence of exon 2, indicating that the variant mRNA is generated by alternative splicing. The variant mRNA as well as the FGF-5 mRNA was detected in the embryo and adult brain. This is the first description of the mRNA for a truncated form of FGF within the FGF family.

引用

页码：31 / 33

页数：3

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