The evolution of isochores

被引：322

作者：

Eyre-Walker, A ^{[1
]}

Hurst, LD

机构：

[1] Univ Sussex, Ctr Study Evolut, Brighton BN1 9QG, E Sussex, England

[2] Univ Sussex, Sch Biol Sci, Brighton BN1 9QG, E Sussex, England

[3] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

NATURE REVIEWS GENETICS | 2001年 / 2卷 / 07期

关键词：

D O I：

10.1038/35080577

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.

引用

页码：549 / 555

页数：7

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