Sensing the fat:: Fatty acid metabolism in the hypothalamus and the melanocortin system

被引：52

作者：

López, M ^{[1
]}

Tovar, S ^{[1
]}

Vázquez, MJ ^{[1
]}

Nogueiras, R ^{[1
]}

Señarís, R ^{[1
]}

Diéguez, C ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Sch Med, Dept Physiol, Santiago De Compostela 15705, Spain

来源：

PEPTIDES | 2005年 / 26卷 / 10期

关键词：

AGRP; fatty acids; fatty acid synthase; feeding; malonyl-CoA; obesity; POMC;

D O I：

10.1016/j.peptides.2004.11.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent evidence has demonstrated that circulating long chain fatty acids act as nutrient abundance signals in the hypothalamus. Moreover, pharmacological inhibition of fatty acid synthase (FAS) results in profound decrease in food intake and body weight in rodents. These anorectic actions are mediated by the modulation of hypothalamic neuropeptide systems, such as melanocortins. In this review, we summarize what is known about lipid sensing and fatty acid metabolism in the hypothalamus. Understanding these molecular mechanisms could provide new pharmacological targets for the treatment of obesity and appetite disorders, as well as novel concepts in the nutritional design. (c) 2005 Elsevier Inc. All rights reserved.

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收藏

页码：1753 / 1758

页数：6

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