Genomics and the Multifactorial Nature of Human Autoimmune Disease

被引：244

作者：

Cho, Judy H. ^{[1
,2
]}

Gregersen, Peter K. ^{[3
]}

机构：

[1] Yale Univ, Dept Med, Sect Digest Dis, New Haven, CT 06520 USA

[2] Yale Univ, Dept Genet, Sect Digest Dis, New Haven, CT 06520 USA

[3] Feinstein Inst Med Res, Robert S Boas Ctr Genom & Human Genet, Manhasset, NY USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2011年 / 365卷 / 17期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; PRIMARY BILIARY-CIRRHOSIS; SCLEROSIS SUSCEPTIBILITY LOCI; INFLAMMATORY-BOWEL-DISEASE; OF-FUNCTION VARIANT; WIDE ASSOCIATION; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; RISK LOCI; TYROSINE-PHOSPHATASE;

D O I：

10.1056/NEJMra1100030

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：1612 / 1623

页数：12

共 83 条

[1] MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].

Abraham, Clara ;

Cho, Judy H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) :2066-2078

[2] Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 [J].

Anderson, Carl A. ;

Boucher, Gabrielle ;

Lees, Charlie W. ;

Franke, Andre ;

D'Amato, Mauro ;

Taylor, Kent D. ;

Lee, James C. ;

Goyette, Philippe ;

Imielinski, Marcin ;

Latiano, Anna ;

Lagace, Caroline ;

Scott, Regan ;

Amininejad, Leila ;

Bumpstead, Suzannah ;

Baidoo, Leonard ;

Baldassano, Robert N. ;

Barclay, Murray ;

Bayless, Theodore M. ;

Brand, Stephan ;

Buening, Carsten ;

Colombel, Jean-Frederic ;

Denson, Lee A. ;

De Vos, Martine ;

Dubinsky, Marla ;

Edwards, Cathryn ;

Ellinghaus, David ;

Fehrmann, Rudolf S. N. ;

Floyd, James A. B. ;

Florin, Timothy ;

Franchimont, Denis ;

Franke, Lude ;

Georges, Michel ;

Glas, Juergen ;

Glazer, Nicole L. ;

Guthery, Stephen L. ;

Haritunians, Talin ;

Hayward, Nicholas K. ;

Hugot, Jean-Pierre ;

Jobin, Gilles ;

Laukens, Debby ;

Lawrance, Ian ;

Lemann, Marc ;

Levine, Arie ;

Libioulle, Cecile ;

Louis, Edouard ;

McGovern, Dermot P. ;

Milla, Monica ;

Montgomery, Grant W. ;

Morley, Katherine I. ;

Mowat, Craig .

NATURE GENETICS, 2011, 43 (03) :246-U94

[3] Development of autoantibodies before the clinical onset of systemic lupus erythematosus [J].

Arbuckle, MR ;

McClain, MT ;

Rubertone, MV ;

Scofield, RH ;

Dennis, GJ ;

James, JA ;

Harley, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (16) :1526-1533

[4] Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling [J].

Arechiga, Adrian F. ;

Habib, Tania ;

He, Yantao ;

Zhang, Xian ;

Zhang, Zhong-Yin ;

Funk, Andrew ;

Buckner, Jane H. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (06) :3343-3347

[5] Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 [J].

Bahlo, Melanie ;

Booth, David R. ;

Broadley, Simon A. ;

Brown, Matthew A. ;

Foote, Simon J. ;

Griffiths, Lyn R. ;

Kilpatrick, Trevor J. ;

Lechner-Scott, Jeanette ;

Moscato, Pablo ;

Perreau, Victoria M. ;

Rubio, Justin P. ;

Scott, Rodney J. ;

Stankovich, Jim ;

Stewart, Graeme J. ;

Taylor, Bruce V. ;

Wiley, James ;

Clarke, Glynnis ;

Cox, Mathew B. ;

Csurhes, Peter A. ;

Danoy, Patrick ;

Drysdale, Karen ;

Field, Judith ;

Foote, Simon J. ;

Greer, Judith M. ;

Guru, Preethi ;

Hadler, Johanna ;

McMorran, Brendan J. ;

Jensen, Cathy J. ;

Johnson, Laura J. ;

McCallum, Ruth ;

Merriman, Marilyn ;

Merriman, Tony ;

Pryce, Karen ;

Tajouri, Lotfi ;

Wilkins, Ella J. ;

Browning, Brian L. ;

Browning, Sharon R. ;

Perera, Devindri ;

Butzkueven, Helmut ;

Carroll, William M. ;

Chapman, Caron ;

Kermode, Allan G. ;

Marriott, Mark ;

Mason, Deborah ;

Heard, Robert N. ;

Pender, Michael P. ;

Slee, Mark ;

Tubridy, Niall ;

Willoughby, Ernest .

NATURE GENETICS, 2009, 41 (07) :824-U84

[6] Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes [J].

Barrett, Jeffrey C. ;

Clayton, David G. ;

Concannon, Patrick ;

Akolkar, Beena ;

Cooper, Jason D. ;

Erlich, Henry A. ;

Julier, Cecile ;

Morahan, Grant ;

Nerup, Jorn ;

Nierras, Concepcion ;

Plagnol, Vincent ;

Pociot, Flemming ;

Schuilenburg, Helen ;

Smyth, Deborah J. ;

Stevens, Helen ;

Todd, John A. ;

Walker, Neil M. ;

Rich, Stephen S. .

NATURE GENETICS, 2009, 41 (06) :703-707

[7] The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis [J].

Begovich, AB ;

Caillier, SJ ;

Alexander, HC ;

Penko, JM ;

Hauser, SL ;

Barcellos, LF ;

Oksenberg, JR .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (01) :184-187

[8] The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 [J].

Bennett, CL ;

Christie, J ;

Ramsdell, F ;

Brunkow, ME ;

Ferguson, PJ ;

Whitesell, L ;

Kelly, TE ;

Saulsbury, FT ;

Chance, PF ;

Ochs, HD .

NATURE GENETICS, 2001, 27 (01) :20-21

[9] Ubiquitylation in innate and adaptive immunity [J].

Bhoj, Vijay G. ;

Chen, Zhijian J. .

NATURE, 2009, 458 (7237) :430-437

[10] A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes [J].

Cargill, Michele ;

Schrodi, Steven J. ;

Chang, Monica ;

Garcia, Veronica E. ;

Brandon, Rhonda ;

Callis, Kristina P. ;

Matsunami, Nori ;

Ardlie, Kristin G. ;

Civello, Daniel ;

Catanese, Joseph J. ;

Leong, Diane U. ;

Panko, Jackie M. ;

McAllister, Linda B. ;

Hansen, Christopher B. ;

Papenfuss, Jason ;

Prescott, Stephen M. ;

White, Thomas J. ;

Leppert, Mark F. ;

Krueger, Gerald G. ;

Begovich, Ann B. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (02) :273-290

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