Quantitative-trait locus for specific language and reading deficits on chromosome 6p

被引：203

作者：

Gayán, J ^{[1
]}

Smith, SD

Cherny, SS

Cardon, LR

Fulker, DW

Brower, AM

Olson, RK

Pennington, BF

DeFries, JC

机构：

[1] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA

[2] Boys Town Natl Res Hosp, Ctr Hereditary Commun Disorders, Omaha, NE 68131 USA

[3] Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London, England

[4] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

[5] Univ Denver, Dept Psychol, Denver, CO USA

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 1999年 / 64卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1086/302191

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Reading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings.

引用

页码：157 / 164

页数：8

共 45 条

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