SIRT1: new avenues of discovery for disorders of oxidative stress

被引：203

作者：

Chong, Zhao Zhong ^{[1
,2
,3
]}

Shang, Yan Chen ^{[1
,2
,3
]}

Wang, Shaohui ^{[1
,2
,3
]}

Maiese, Kenneth ^{[1
,2
,3
]}

机构：

[1] Univ Med & Dent New Jersey, Sch Med, Ctr Canc, Newark, NJ 07101 USA

[2] Univ Med & Dent New Jersey, Sch Med, Lab Cellular & Mol Signaling, Newark, NJ 07101 USA

[3] Univ Med & Dent New Jersey, Sch Med, Dept Neurol & Neurosci, Newark, NJ 07101 USA

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2012年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

akt; Alzheimer's disease; AMP-activated protein kinase (AMPK); apoptosis; autophagy; cancer; cardiovascular disease; diabetes mellitus; erythropoietin; forkhead transcription factor; FoxO; insulin; neurodegenerative disease; NF-kappa B; nicotinamide adenine dinucleotide (NAD plus ); oxidative stress; Parkinson's disease; peroxisome proliferators activated receptor (PPAR); peroxisome proliferators-activated receptor-gamma coactivator (PGC); protein tyrosine phosphatase; resveratrol; SIRT1; sirtuin; NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; CELL-SURVIVAL; CARDIAC-HYPERTROPHY; NUCLEAR TRANSLOCATION; VASCULAR INTEGRITY; CEREBRAL-ISCHEMIA; REGULATES SIRT1; RESVERATROL; ERYTHROPOIETIN;

D O I：

10.1517/14728222.2012.648926

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Introduction: The sirtuin SIRT1 is expressed throughout the body, has broad biological effects and can significantly affect both cellular survival and longevity during acute and long-term injuries, which involve both oxidative stress and cell metabolism. Areas covered: SIRT1 has an intricate role in the pathology, progression, and treatment of several disease entities, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, tumorigenesis, cardiovascular disease with myocardial injury and atherosclerosis, metabolic disease, and aging-related disease. New areas of study in these disciplines, with discussion of the cellular biology, are highlighted. Expert opinion: Novel signaling pathways for SIRT1, which can be targeted to enhance cellular protection and potentially extend lifespan, continue to emerge. Investigations that can further determine the intracellular signaling, trafficking and post-translational modifications that occur with SIRT1 in a variety of cell systems and environments will allow us to further translate this knowledge into effective therapeutic strategies that will be applicable to multiple systems of the body.

引用

页码：167 / 178

页数：12

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