A MAP kinase homologue from the human malaria parasite, Plasmodium falciparum

被引：52

作者：

Doerig, CM

Parzy, D

Langsley, G

Horrocks, P

Carter, R

Doerig, CD

机构：

[1] FAC MED MARSEILLE, INSERM, U399, F-13385 MARSEILLE 05, FRANCE

[2] INST TROP MED, SERV SANTE ARMEES, F-13998 MARSEILLE, FRANCE

[3] INST PASTEUR, F-75724 PARIS, FRANCE

[4] UNIV EDINBURGH, INST CELL & MOL BIOL, EDINBURGH EH9 3JR, MIDLOTHIAN, SCOTLAND

[5] UNIV EDINBURGH, INST CELL ANIM & POPULAT BIOL, EDINBURGH EH9 3JT, MIDLOTHIAN, SCOTLAND

来源：

GENE | 1996年 / 177卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

mitogen-activated protein kinase; parasitic protozoans; A; adenosine;

D O I：

10.1016/0378-1119(96)00281-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Pfmap-1, a gene encoding a novel protein kinase, has been identified in the human malaria parasite Plasmodium falciparum, using the polymerase chain reaction with degenerate oligodeoxyribonucleotides designed to hybridise to conserved regions of cdc2-related kinases. Computer comparison with other protein kinases strongly suggests that the protein encoded by this gene is closely related to mitogen-activated protein (MAP) kinases, which play important roles in eukaryotic adaptative response and signal transduction. In addition to the conserved MAP kinase catalytic domain, Pfmap-1 contains a highly charged C-terminal extension that includes two sets of repeated amino acid motifs. Pfmap-1 is located on chromosome 14 of P. falciparum, and its mRNA has a size of 3.7 kb.

引用

页码：1 / 6

页数：6

共 31 条

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