Glycosidase pro. ling with immobilised glycosidase-inhibiting iminoalditols -: A proof-of-concept study

被引：12

作者：

Steiner, Andreas J. ^{[1
]}

Stuetz, Arnold E. ^{[1
]}

Wrodnigg, Tanja M. ^{[1
]}

Tarling, Chris A. ^{[2
]}

Withers, Stephen G. ^{[2
]}

Hermetter, Albin ^{[3
]}

Schmidinger, Hannes ^{[3
]}

机构：

[1] Graz Univ Technol, Glycogrp, Inst Organ Chem, A-8010 Graz, Austria

[2] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z3, Canada

[3] Graz Univ Technol, Inst Biochem, A-8010 Graz, Austria

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 06期

基金：

加拿大健康研究院;

关键词：

iminoalditol; iminosugar chip; immobilisation; glycosidase inhibitor;

D O I：

10.1016/j.bmcl.2008.01.124

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three typical glycosidase-inhibiting iminoalditols were attached to a polyamine surface displayed on a silicon chip. Exposure to a representative beta-glucosidase revealed selective binding events reflecting the different structural features of the inhibitors probed in this study. This provides a proof-of-concept for the successful exploitation of microarrays of typical reversible glycosidase inhibitors of the iminosugar family. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1922 / 1925

页数：4

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