Carbohydrate microarrays: Survey of fabrication techniques

被引：46

作者：

Culf, Adrian S.

Cuperlovic-Culf, Miroslava

Ouellette, Rodney J.

机构：

[1] Mt Allison Univ, Atlantic Canc Res Inst, Moncton, NB E1C 8X3, Canada

[2] Mt Allison Univ, Atlantic Microarray Facil, Moncton, NB E1C 8X3, Canada

[3] Mt Allison Univ, Dept Chem, Moncton, NB E1C 8X3, Canada

[4] Univ Moncton, Dept Biol, Moncton, NB E1A 3E9, Canada

来源：

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY | 2006年 / 10卷 / 03期

关键词：

D O I：

10.1089/omi.2006.10.289

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Carbohydrate microarrays are being developed in order to decipher the information content of the glycome. This postgenomic activity is necessary because of the complexity of protein biosynthesis and post-translational modifications that cannot currently be detected at the genome level. This review looks, in detail, at the experimental approaches that have been taken in the fabrication and preparation of carbohydrate microarrays, glycan arrays and glyco-chips. Tether structures, glycan solution preparation, detection methods and applications have been gathered together in a tabular format.

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页码：289 / 310

页数：22

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