A new, ring closing metathesis-based synthesis of (-)-fumagillol

被引：40

作者：

Boiteau, JG ^{[1
]}

Van de Weghe, P ^{[1
]}

Eustache, J ^{[1
]}

机构：

[1] Univ Haute Alsace, Ecole Natl Super Chim, CNRS, Lab Chim Organ & Bioorgan, F-68093 Mulhouse, France

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 17期

关键词：

D O I：

10.1021/ol016343z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new strategy to access the fumagillin/fumagillol skeleton is proposed. An Evans aldolization and a RCM involving an enone are used for the preparation of a key cyclohexanone intermediate, which was readily converted to fumagillol. The synthesis also features an efficient preparation of isogeraniol and isogeranic acid.

引用

页码：2737 / 2740

页数：4

共 32 条

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