How nanoparticles encapsulating fluorophores allow a double detection of biomolecules by localized surface plasmon resonance and luminescence

被引：20

作者：

Barbillon, G. ^{[2
,3
]}

Faure, A. C. ^{[2
]}

El Kork, N. ^{[2
]}

Moretti, P. ^{[2
]}

Roux, S. ^{[2
]}

Tillement, O. ^{[2
]}

Ou, M. G. ^{[1
]}

Descamps, A. ^{[1
]}

Perriat, P. ^{[1
]}

Vial, A. ^{[3
]}

Bijeon, J-L ^{[3
]}

Marquette, C. A. ^{[4
]}

Jacquier, B. ^{[2
]}

机构：

[1] Univ Lyon, CNRS UMR 5510, INSA Lyon, F-69621 Villeurbanne, France

[2] Univ Lyon 1, CNRS UMR 5620, LPCML, F-69622 Villeurbanne, France

[3] Univ Technol Troyes, Inst Charles Delaunay, CNRS FRE 2848, LNIO, F-10010 Troyes, France

[4] Univ Lyon 1, Lab Genie Enzymat & Biomol, CNRS ICBMS, UMR 5246, F-69622 Villeurbanne, France

来源：

NANOTECHNOLOGY | 2008年 / 19卷 / 03期

关键词：

D O I：

10.1088/0957-4484/19/03/035705

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The paper shows how polysiloxane particles encapsulating fluorophores can be successfully used to detect biotin-streptavidin binding by two types of technique. After functionalization of the particles by streptavidin, the fixation of the biomolecule can indeed be detected by a shift of the localized surface plasmon resonance of the biotinylated gold dots used as substrate and by the luminescence of the fluorophores evidenced by scanning near-field optical microscopy. The development of particles allowing such a double detection opens a route for increasing the reliability of biological detection and for multi-labelling strategies crossing both detection principles.

引用

页数：7

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