Platelets in inflammation and thrombosis

被引：416

作者：

Wagner, DD

Burger, PC

机构：

[1] Ctr Blood Res, Inst Biomed Res, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2003年 / 23卷 / 12期

关键词：

platelets; inflammation; thrombosis; atherosclerosis; hemostasis;

D O I：

10.1161/01.ATV.0000095974.95122.EC

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For many years it has been known that platelets play an important role in thrombosis and hemostasis. In recent times, however, it has become evident that platelets also have relevant functions in inflammation. It was shown that thrombosis and inflammation share several key molecular mechanisms and in fact are 2 intrinsically linked processes. In this review, we intend to give a short overview with emphasis on work stemming from our laboratory.

引用

收藏

页码：2131 / 2137

页数：7

相关论文

共 91 条

[51] Nitric oxide insufficiency, platelet activation, and arterial thrombosis [J].

Loscalzo, J .

CIRCULATION RESEARCH, 2001, 88 (08) :756-762

[52] Requirement for CD154 in the progression of atherosclerosis [J].

Lutgens, E ;

Gorelik, L ;

Daemen, MJAP ;

de Muinck, E ;

Grewal, IS ;

Koteliansky, VE ;

Flavell, RA .

NATURE MEDICINE, 1999, 5 (11) :1313-1316

[53] Reduction of atherosclerosis in mice by inhibition of CD40 signalling [J].

Mach, F ;

Schönbeck, U ;

Sukhova, GK ;

Atkinson, E ;

Libby, P .

NATURE, 1998, 394 (6689) :200-203

[54] A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation [J].

Massberg, S ;

Brand, K ;

Grüner, S ;

Page, S ;

Müller, E ;

Müller, I ;

Bergmeier, W ;

Richter, T ;

Lorenz, M ;

Konrad, I ;

Nieswandt, B ;

Gawaz, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (07) :887-896

[55] Platelet-endothelial cell interactions during ischemia/reperfusion: The role of P-selectin [J].

Massberg, S ;

Enders, G ;

Leiderer, R ;

Eisenmenger, S ;

Vestweber, D ;

Krombach, F ;

Messmer, K .

BLOOD, 1998, 92 (02) :507-515

[56]

MATSUSHITA K, IN PRESS NITRIC OXID

[57] LEUKOCYTE ROLLING AND EXTRAVASATION ARE SEVERELY COMPROMISED IN P-SELECTIN-DEFICIENT MICE [J].

MAYADAS, TN ;

JOHNSON, RC ;

RAYBURN, H ;

HYNES, RO ;

WAGNER, DD .

CELL, 1993, 74 (03) :541-554

[58] GMP-140, A PLATELET ALPHA-GRANULE MEMBRANE-PROTEIN, IS ALSO SYNTHESIZED BY VASCULAR ENDOTHELIAL-CELLS AND IS LOCALIZED IN WEIBEL-PALADE BODIES [J].

MCEVER, RP ;

BECKSTEAD, JH ;

MOORE, KL ;

MARSHALLCARLSON, L ;

BAINTON, DF .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (01) :92-99

[59] Localized reduction of atherosclerosis in von Willebrand factor-deficient mice [J].

Methia, N ;

André, P ;

Denis, CV ;

Economopoulos, M ;

Wagner, DD .

BLOOD, 2001, 98 (05) :1424-1428

[60] New and effective treatment of experimentally induced venous thrombosis with anti-inflammatory rPSGL-Ig [J].

Myers, D ;

Wrobleski, S ;

Londy, F ;

Fex, B ;

Hawley, A ;

Schaub, R ;

Greenfield, L ;

Wakefield, T .

THROMBOSIS AND HAEMOSTASIS, 2002, 87 (03) :374-382

← 1 2 3 4 5 6 7 8 9 10 →