Nanoparticles for drug delivery: The need for precision in reporting particle size parameters

被引：844

作者：

Gaumet, Marie ^{[1
]}

Vargas, Angelica ^{[1
]}

Gurny, Robert ^{[1
]}

Delie, Florence ^{[1
]}

机构：

[1] Univ Lausanne, Univ Geneva, Dept Pharmaceut & Biopharmaceut, CH-1211 Geneva 4, Switzerland

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2008年 / 69卷 / 01期

关键词：

nanoparticle; biodistribution; size determination; drug carrier;

D O I：

10.1016/j.ejpb.2007.08.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polymeric drug-loaded nanoparticles have been extensively studied in the field of drug delivery. Biodistribution depends on the physicochemical properties of particles, especially size. The global message from the literature is that small particles have an enhanced ability to reach their target. The present review highlights the difficulties in validating the data from biodistribution studies without accurate particle size determination. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：1 / 9

页数：9

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