Identification of functionally distinct isoforms of the N-type Ca2+ channel in rat sympathetic ganglia and brain

被引:142
作者
Lin, ZX
Haus, S
Edgerton, J
Lipscombe, D
机构
[1] Department of Neuroscience, Brown University, Providence
关键词
D O I
10.1016/S0896-6273(01)80054-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The N channel is critical for regulating release of neurotransmitter at many synapses, and even subtle differences in its activity would be expected to influence the efficacy of synaptic transmission. Although several splice variants of the N channel are expressed in the mammalian nervous system, their biological importance is presently unclear. Here, we show that variants of the alpha(1B) subunit of the N channel are expressed in sympathetic ganglia and that alternative splicing within IllS3-S4 and IVS3-S4 generate kinetically distinct channels. We further show a striking difference between the expression pattern of the S3-S4 variants in brain and peripheral ganglia and conclude that the brain-dominant form of the N channel gates 2- to 4-fold more rapidly than that predominant in ganglia.
引用
收藏
页码:153 / 166
页数:14
相关论文
共 64 条
  • [51] A CONSERVED AU SEQUENCE FROM THE 3' UNTRANSLATED REGION OF GM-CSF MESSENGER-RNA MEDIATES SELECTIVE MESSENGER-RNA DEGRADATION
    SHAW, G
    KAMEN, R
    [J]. CELL, 1986, 46 (05) : 659 - 667
  • [52] DISTINCT CALCIUM CHANNELS ARE GENERATED BY ALTERNATIVE SPLICING AND ARE DIFFERENTIALLY EXPRESSED IN THE MAMMALIAN CNS
    SNUTCH, TP
    TOMLINSON, WJ
    LEONARD, JP
    GILBERT, MM
    [J]. NEURON, 1991, 7 (01) : 45 - 57
  • [53] STRUCTURE AND FUNCTIONAL EXPRESSION OF A MEMBER OF THE LOW-VOLTAGE ACTIVATED CALCIUM-CHANNEL FAMILY
    SOONG, TW
    STEA, A
    HODSON, CD
    DUBEL, SJ
    VINCENT, SR
    SNUTCH, TP
    [J]. SCIENCE, 1993, 260 (5111) : 1133 - 1136
  • [54] A BETA-SUBUNIT NORMALIZES THE ELECTROPHYSIOLOGICAL PROPERTIES OF A CLONED N-TYPE CA2+ CHANNEL ALPHA(1)-SUBUNIT
    STEA, A
    DUBEL, SJ
    PRAGNELL, M
    LEONARD, JP
    CAMPBELL, KP
    SNUTCH, TP
    [J]. NEUROPHARMACOLOGY, 1993, 32 (11) : 1103 - 1116
  • [55] DETERMINANTS OF PKC-DEPENDENT MODULATION OF A FAMILY OF NEURONAL CALCIUM CHANNELS
    STEA, A
    SOONG, TW
    SNUTCH, TP
    [J]. NEURON, 1995, 15 (04) : 929 - 940
  • [56] DIFFERENT TYPES OF CALCIUM CHANNELS MEDIATE CENTRAL SYNAPTIC TRANSMISSION
    TAKAHASHI, T
    MOMIYAMA, A
    [J]. NATURE, 1993, 366 (6451) : 156 - 158
  • [57] INDUCTION OF ENDOGENOUS CHANNELS BY HIGH-LEVELS OF HETEROLOGOUS MEMBRANE-PROTEINS IN XENOPUS OOCYTES
    TZOUNOPOULOS, T
    MAYLIE, J
    ADELMAN, JP
    [J]. BIOPHYSICAL JOURNAL, 1995, 69 (03) : 904 - 908
  • [58] CALCIUM MODULATION AND HIGH CALCIUM PERMEABILITY OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS
    VERNINO, S
    AMADOR, M
    LUETJE, CW
    PATRICK, J
    DANI, JA
    [J]. NEURON, 1992, 8 (01) : 127 - 134
  • [59] ACTIVATION OF A MUSCARINIC RECEPTOR SELECTIVELY INHIBITS A RAPIDLY INACTIVATED CA-2+ CURRENT IN RAT SYMPATHETIC NEURONS
    WANKE, E
    FERRONI, A
    MALGAROLI, A
    AMBROSINI, A
    POZZAN, T
    MELDOLESI, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (12) : 4313 - 4317
  • [60] BIOCHEMICAL-PROPERTIES AND SUBCELLULAR-DISTRIBUTION OF AN N-TYPE CALCIUM CHANNEL-ALPHA-1 SUBUNIT
    WESTENBROEK, RE
    HELL, JW
    WARNER, C
    DUBEL, SJ
    SNUTCH, TP
    CATTERALL, WA
    [J]. NEURON, 1992, 9 (06) : 1099 - 1115