Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas

被引:487
作者
RicoHesse, R
Harrison, LM
Salas, RA
Tovar, D
Nisalak, A
Ramos, C
Boshell, J
deMesa, MTR
Nogueira, RMR
daRosa, AT
机构
[1] YALE UNIV, SCH MED, DEPT EPIDEMIOL & PUBL HLTH, NEW HAVEN, CT 06520 USA
[2] MINIST SALUD, INST NACL HIGIENE RAFAEL RANGEL, CARACAS, VENEZUELA
[3] ARMED FORCES RES INST MED SCI, DEPT VIROL, BANGKOK 10400, THAILAND
[4] CISEI, INST NACL SALUD PUBL, CUERNAVACA, MORELOS, MEXICO
[5] MINIST SALUD, INST NACL SALUD, BOGOTA, COLOMBIA
[6] UNIV VALLE, DEPT MICROBIOL, CALI, COLOMBIA
[7] INST OSWALDO CRUZ, DEPT VIROL, BR-20001 RIO DE JANEIRO, BRAZIL
[8] FUNDACAO NACL SAUDE, INST EVANDRO CHAGAS, BELEM, PARA, BRAZIL
关键词
D O I
10.1006/viro.1997.8504
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The recent emergence and spread of dengue hemorrhagic fever in the Americas have been a major source of concern. Efforts to control this disease are dependent on understanding the pathogenicity of dengue viruses and their transmission dynamics. Pathogenicity studies have been hampered by the lack of in vitro or in vivo models of severe dengue disease. Alternatively, molecular epidemiologic studies which associate certain dengue Virus genetic types with severe dengue outbreaks may point to strains with increased pathogenicity. The comparison of nucleotide sequences (240 bp) from the E/NS1 gene region of the dengue virus genome has been shown to reflect evolutionary relationships and geographic origins of dengue virus strains. This approach was used to demonstrate an association between the introduction of two distinct genotypes of dengue type 2 virus and the appearance of dengue hemorrhagic fever in the Americas. Phylogenetic analyses suggest that these genotypes originated in Southeast Asia and that they displaced the native, American genotype in at least four countries. Vaccination and other control efforts should therefore be directed at decreasing the transmission of these ''virulent'' genotypes. (C) 1997 Academic Press.
引用
收藏
页码:244 / 251
页数:8
相关论文
共 34 条
  • [31] *WHO, 1994, WEEKLY EPIDEMIOL REC, V69, P177
  • [32] *WHO, 1996, 117 WHO
  • [33] *WHO, 1976, DENGUE NEWSL SE ASIA, V2, P1
  • [34] World Health Organization, 1986, DENG HAEM FEV DIAGN