The selenium link: the missing link in our understanding of biochemical trigger reactions?

被引:6
作者
Nyberg-Swenson, BE
机构
[1] 43136 Mol̈Indal
关键词
D O I
10.1054/mehy.1997.0633
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
'Inorganic' selenium (Se), e.g. selenite and selenate, is assumed to be transformed into selenide and to be incorporated into selenoproteins, but this has never been proved. There is evidence, however, that Vitamin C reduces selenite to elemental Se. Elemental sulphur (S) and Se bind easily to sulphides and selenides, forming links containing two or more S or Se atoms. Such links exist in natural minerals and have been found in proteins in living organisms. There are many indications that selenocysteine in special proteins combines with elemental Se to form Se links that transfer electrons from redoxable agents to oxygen (O-2). This implies a reduction to hydrogen peroxide (H2O2) or H2O, while gaining energy and achieving trigger effects. H2O2 supplies anaerobic reactions with energy eventually via adenosine 5'-triphosphate (ATP) or guanosine 5'-triphosphate (GTP). Without Se links, redoxable agents can be oxidized by oxygen, which leads to the formation of oxygen products and inhibition of further electron transference. Nitrous oxide (NO) is one product of oxidation that, firmly binding to heme structures, may result in a system of protection. NO can prevent O-2 from binding to them and thereby stop destroying oxidations.
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页码:125 / 131
页数:7
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