Synthesis of (±)-cassumunins A and B, new curcuminoid antioxidants having protective activity of the living cell against oxidative damage

被引：33

作者：

Masuda, T ^{[1
]}

Matsumura, H

Oyama, Y

Takeda, Y

Jitoe, A

Kida, A

Hidaka, K

机构：

[1] Univ Tokushima, Fac Integrated Arts & Sci, Tokushima 770, Japan

[2] Osaka City Univ, Fac Human Life Sci, Osaka 558, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 05期

关键词：

D O I：

10.1021/np970555g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A chemical synthesis of cassumunins A (1) and B (2), natural curcuminoid antioxidants, was developed. The synthesis was started from o-vanillin and after nine reaction steps resulted in 20% and 26% overall yields of 1 and 2, respectively. The synthetic cassumunins showed stronger protective activity than curcumin against oxidative cell death induced by hydrogen peroxide in a rat thymocyte system.

引用

页码：609 / 613

页数：5

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