Synthesis and radioprotective study of new siladithioacetals and germadithioacetals

被引：5

作者：

Célariès, B

Amourette, C

Lion, C

Rima, G

机构：

[1] Univ Toulouse 3, CNRS, UMR 5069, Lab Heterochim Fondamentale & Appl, F-31062 Toulouse 4, France

[2] Ctr Rech Serv Sante Armees, F-38702 La Tronche, France

[3] Univ Paris 07, CNRS, ITODYS, F-75005 Paris, France

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2003年 / 17卷 / 08期

关键词：

siladithioacetals; germadithioacetals; toxicity; LD50; naphthylethylimidazoline; radioprotective activity;

D O I：

10.1002/aoc.472

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of organosilicon and organogermanium compounds derived from cysteamine, methylcysteamine and 2-[1-(1-naphthyl)ethyl]-2-imidazoline have been prepared and their radiopharmacological properties (radioprotective activity and toxicity) have been determined in mice. A number of these new organometallic derivatives have been found to possess radioprotective activity. We have also noted a notable decrease of the toxicity and a fairly large increase in the radioprotective activity in comparison with the unsubstituted organic molecules. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：561 / 569

页数：9

共 54 条

[11]

DIMARTINO MJ, 1986, J PHARMACOL EXP THER, V236, P103

[12]

EISENHAUER E, 1985, INVEST NEW DRUG, V3, P307

[13]

FATOME M, 1984, EUR J MED CHEM, V19, P119

[14] STUDY OF GERMATHIAZOLIDINES AND GERMYLATED DITHIOACETALS DERIVED FROM N-SUBSTITUTED CYSTEAMINE AND METHYLCYSTEAMINE - SYNTHESIS AND RADIOPROTECTIVE ACTIVITY [J].

FATOME, M ;

SENTENACROUMANOU, H ;

LION, C ;

SATGE, J ;

RIMA, G .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1988, 23 (03) :257-266

[15]

Finney D. J, 1947, PROBIT ANAL

[16]

GAR TK, 1993, IZV AKAD NAUK K, V10, P1793

[17]

GOODMAN S, 1987, J COMP MED, V4, P34

[18]

HACHISU M, 1983, J PHARMACOBIO-DYNAM, V6, P814

[19]

KAKIMOTO N, 1985, HETEROCYCLES, V23, P2681

[20]

Kobayashi H, 1986, Gan To Kagaku Ryoho, V13, P2588

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