Spectral analysis of wakefulness and REM sleep EEG in patients with sleep apnoea syndrome

被引:78
作者
Morisson, F
Lavigne, G
Petit, D
Nielsen, T
Malo, J
Montplaisir, J
机构
[1] Hop Sacre Coeur, Ctr Etude Sommeil, Montreal, PQ H4J 1C5, Canada
[2] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada
[3] Hop Sacre Coeur, Dept Chest Med, Montreal, PQ H4J 1C5, Canada
[4] Univ Montreal, Fac Dent, Montreal, PQ H3C 3J7, Canada
关键词
cerebral hypoxaemia; electroencephalographic topography; obstructive sleep apnoea syndrome; quantitative electroencephalographic analysis; wakefulness;
D O I
10.1183/09031936.98.11051135
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Neuropsychological investigations of patients with obstructive sleep apnoea syndrome (OSAS) have shown impairments in such basic functions as memory, attention and executive control. Since executive functions are known to be dependent on the integrity of the frontal lobe, it was hypothesized that OSAS may be associated with hypoxaemic frontal lobe dysfunction, To test this hypothesis, 21 apnoeic patients and 10 normal controls mere studied with quantitative electroencephalographic (EEG) methods during rapid eye movement (REM) sleep, when most apnoeic events occur and during wakefulness. In apnoeic patients, EEG slowing in REM sleep was observed over frontal, central and parietal regions, while EEG slowing during wakefulness was observed over all cortical regions examined. A positive correlation was found between EEG slowing during wakefulness and oxygen desaturation during the night, Contrary. to the hypothesis, these electroencephalographic changes mere not localized only. to the frontal region. This result may explain the wide range of neuropsychological deficits noted in patients with obstructive sleep apnoea syndrome, in addition to their poor performance in tasks of executive functioning.
引用
收藏
页码:1135 / 1140
页数:6
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