Exogenous Cushing's syndrome and glucocorticoid withdrawal

被引:134
作者
Hopkins, RL [1 ]
Leinung, MC [1 ]
机构
[1] Albany Med Coll, Div Endocrinol & Metab, Albany, NY 12008 USA
关键词
D O I
10.1016/j.ecl.2005.01.013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Glucocorticoid therapy in various forms is extremely common for a wide range of inflammatory autoimmune, and neoplastic disorders. It is therefore important for the physician to be aware of the possibility of both iatrogenic and factitious Cushing's syndrome. Although most common with oral therapy, it is also important to be alert to the fact that all forms of glucocorticoid delivery have the potential to cause Cushing's syndrome. Withdrawal from chronic glucocorticoid therapy presents significant challenges. These include the possibility of adrenal insufficiency after discontinuation of steroid therapy, recurrence of underlying disease as the glucocorticoid is being withdrawn, and the possibility of steroid withdrawal symptoms. Nonetheless, with patience and persistence, a reasonable approach to withdrawal of glucocorticoid therapy can be achieved.
引用
收藏
页码:371 / +
页数:15
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