B vitamin status and inflammatory markers

被引:41
作者
Folsom, AR
Desvarieux, M
Nieto, FJ
Boland, LL
Ballantyne, CM
Chambless, LE
机构
[1] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55454 USA
[2] Univ Wisconsin, Sch Med, Dept Populat Hlth Sci, Madison, WI 53705 USA
[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[4] Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC 27514 USA
关键词
C-reactive protein; fibrinogen; leukocytes; pyridoxal-5 '-phosphate; vitamin B12; folate;
D O I
10.1016/S0021-9150(03)00161-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Limited evidence has suggested that low levels of circulating pyridoxal-5'-phosphate (PLP) may be associated with elevation of the inflammatory marker, C-reactive protein (CRP). We sought to determine whether the reported association of CRP with PLP was specific versus generalizable to other inflammation or hemostasis markers. Among 519 healthy middle aged adults in the Atherosclerosis Risk in Communities (ARIC) Study, we analyzed the cross-sectional relation of homocysteine, plasma and dietary B vitamin levels with multiple markers implicated in inflammation, endothelial dysfunction, or thrombogenesis: CRP, fibrinogen, white blood cell count, intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, factor VIII, and von Willebrand factor. There was no significant association (P > 0.05) of von Willebrand factor, I-CAM, or V-CAM with any of the plasma or dietary measures examined, and no marker was associated significantly with serum homocysteine. Contrary to our hypothesis, plasma PLP was not associated with CRP concentration. A higher white blood cell count was associated with lower B vitamin status (lower plasma PLP and folate, lower dietary B6 and B12), though not with use of vitamin supplements. In ostensibly healthy adults. B-vitamin status is not a strong correlate of circulating levels of inflammatory markers, cellular adhesion molecules. or thrombogenic factors. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:169 / 174
页数:6
相关论文
共 25 条
[1]   Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over [J].
Bates, CJ ;
Pentieva, KD ;
Prentice, A ;
Mansoor, MA ;
Finch, S .
BRITISH JOURNAL OF NUTRITION, 1999, 81 (03) :191-201
[2]   Improved vascular endothelial function after oral B vitamins - An effect mediated through reduced concentrations of free plasma homocysteine [J].
Chambers, JC ;
Ueland, PM ;
Obeid, OA ;
Wrigley, J ;
Refsum, H ;
Kooner, JS .
CIRCULATION, 2000, 102 (20) :2479-2483
[3]   Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease - Meta-analyses of prospective studies [J].
Danesh, J ;
Collins, R ;
Appleby, P ;
Peto, R .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (18) :1477-1482
[4]  
deJong SC, 1997, THROMB HAEMOSTASIS, V78, P1332
[5]   SERUM VITAMIN-B12 AND BLOOD-CELL VALUES IN VEGETARIANS [J].
DONG, A ;
SCOTT, SC .
ANNALS OF NUTRITION AND METABOLISM, 1982, 26 (04) :209-216
[6]   Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering [J].
Doshi, SN ;
McDowell, IFW ;
Moat, SJ ;
Payne, N ;
Durrant, HJ ;
Lewis, MJ ;
Goodfellow, J .
CIRCULATION, 2002, 105 (01) :22-26
[7]   LEUKOCYTES AND THE RISK OF ISCHEMIC DISEASES [J].
ERNST, E ;
HAMMERSCHMIDT, DE ;
BAGGE, U ;
MATRAI, A ;
DORMANDY, JA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1987, 257 (17) :2318-2324
[8]   Prospective study of hemostatic factors and incidence of coronary heart disease - The Atherosclerosis Risk in Communities (ARIC) Study [J].
Folsom, AR ;
Wu, KK ;
Rosamond, WD ;
Sharrett, AR ;
Chambless, LE .
CIRCULATION, 1997, 96 (04) :1102-1108
[9]   Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins - The atherosclerosis risk in communities (ARIC) study [J].
Folsom, AR ;
Nieto, FJ ;
McGovern, PG ;
Tsai, MY ;
Malinow, MR ;
Eckfeldt, JH ;
Hess, DL ;
Davis, CE .
CIRCULATION, 1998, 98 (03) :204-210
[10]   C-Reactive protein and incident coronary heart disease in the Atherosclerosis Risk In Communities (ARIC) study [J].
Folsom, AR ;
Aleksic, N ;
Catellier, D ;
Juneja, HS ;
Wu, KK .
AMERICAN HEART JOURNAL, 2002, 144 (02) :233-238