The RecQ DNA Helicases in DNA Repair

被引：230

作者：

Bernstein, Kara A. ^{[1
]}

Gangloff, Serge ^{[2
,3
]}

Rothstein, Rodney ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Genet & Dev, New York, NY 10032 USA

[2] CEA, DSV, iRCM, SIGRR,LERA, F-92265 Fontenay Aux Roses, France

[3] CNRS, UMR 217, F-92265 Fontenay Aux Roses, France

来源：

ANNUAL REVIEW OF GENETICS, VOL 44 | 2010年 / 44卷

关键词：

RecQ; Werner syndrome; Bloom syndrome; Rothmund-Thomson syndrome; homologous recombination; DNA repair; BLOOMS-SYNDROME HELICASE; SYNDROME GENE-PRODUCT; TOPOISOMERASE-III-ALPHA; ROTHMUND-THOMSON-SYNDROME; REPLICATION PROTEIN-A; ESCHERICHIA-COLI RECQ; FAITHFUL CHROMOSOME SEGREGATION; HOLLIDAY JUNCTION DISSOLVASOME; WERNERS-SYNDROME PROTEIN; MEIOTIC CROSSING-OVER;

D O I：

10.1146/annurev-genet-102209-163602

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double :Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well IS at specific genomic loci such as telomeres.

引用

页码：393 / 417

页数：25

共 173 条

[11] Unwinding Protein Complexes in ALTernative Telomere Maintenance [J].

Bhattacharyya, Saumitri ;

Sandy, April ;

Groden, Joanna .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 109 (01) :7-15

[12] Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance [J].

Bjergbaek, L ;

Cobb, JA ;

Tsai-Pflugfelder, M ;

Gasser, SM .

EMBO JOURNAL, 2005, 24 (02) :405-417

[13] Physical and functional interaction between p53 and the Werner's syndrome protein [J].

Blander, G ;

Kipnis, J ;

Leal, JFM ;

Yu, CE ;

Schellenberg, GD ;

Oren, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (41) :29463-29469

[14] CONGENITAL TELANGIECTATIC ERYTHEMA RESEMBLING LUPUS ERYTHEMATOSUS IN DWARFS - PROBABLY A SYNDROME ENTITY [J].

BLOOM, D .

AMA AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1954, 88 (06) :754-758

[15] Multiple Pathways Regulate 3′ Overhang Generation at S. cerevisiae Telomeres [J].

Bonetti, Diego ;

Martina, Marina ;

Clerici, Michela ;

Lucchini, Giovanna ;

Longhese, Maria Pia .

MOLECULAR CELL, 2009, 35 (01) :70-81

[16] Ubc9-and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks [J].

Branzei, Dana ;

Sollier, Julie ;

Liberi, Giordano ;

Zhao, Xiaolan ;

Maeda, Daisuke ;

Seki, Masayuki ;

Enomoto, Takemi ;

Ohta, Kunihiro ;

Foiani, Marco .

CELL, 2006, 127 (03) :509-522

[17] SUMOylation regulates Rad18-mediated template switch [J].

Branzei, Dana ;

Vanoli, Fabio ;

Foiani, Marco .

NATURE, 2008, 456 (7224) :915-920

[18] Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity [J].

Brosh, RM ;

Li, JL ;

Kenny, MK ;

Karow, JK ;

Cooper, MP ;

Kureekattil, RP ;

Hickson, ID ;

Bohr, VA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (31) :23500-23508

[19] Functional and physical interaction between WRN helicase and human replication protein A [J].

Brosh, RM ;

Orren, DK ;

Nehlin, JO ;

Ravn, PH ;

Kenny, MK ;

Machwe, A ;

Bohr, VA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18341-18350

[20] RECQ1 possesses DNA branch migration activity [J].

Bugreev, Dmitry V. ;

Brosh, Robert M., Jr. ;

Mazin, Alexander V. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (29) :20231-20242

← 1 2 3 4 5 6 7 8 9 10 →