A simple method for the α-oxygenation of aldehydes

被引：27

作者：

Beshara, CS

Hall, A

Jenkins, RL

Jones, TC

Parry, RT

Thomas, SP

Tomkinson, NCO

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3TB, S Glam, Wales

[2] GlaxoSmithKline Pharmaceut, Neurol & GI Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b418101h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild, efficient and general method for the chemospecific alpha-oxygenation of aldehydes is described. Treatment of a series of aldehydes with N-tert-butyl-O-benzoyl hydroxylamine hydrochloride gives the corresponding alpha-oxygenated carbonyl via a proposed pericyclic rearrangement process.

引用

收藏

页码：1478 / 1480

页数：3

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