Complement deficiencies and systemic lupus erythematosus

被引：221

作者：

Truedsson, Lennart ^{[1
]}

Bengtsson, Anders A. ^{[2
]}

Sturfelt, Gunnar ^{[2
]}

机构：

[1] Lund Univ, Dept Lab Med, Sect Microbiol Immunol & Glycobiol, SE-22362 Lund, Sweden

[2] Lund Univ, Dept Clin Sci, Rheumatol Sect, SE-22185 Lund, Sweden

来源：

AUTOIMMUNITY | 2007年 / 40卷 / 08期

关键词：

autoimmune disease; complement; deficiency; SLE;

D O I：

10.1080/08916930701510673

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencies and SLE could be explained by several mechanisms, including impaired clearance of immune complexes and impaired handling of apoptotic cells, aberrant tolerance induction or changes in cytokine regulation. Also during SLE disease flares, the complement system is activated giving rise to partial deficiency or dysfunction due to consumption. On the other hand, complement also takes part in the inflammatory reaction in the disease that gives rise to the tissue and organ damage. In this review various aspects of the relation between complement and SLE are discussed.

引用

页码：560 / 566

页数：7