Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy

被引：110

作者：

Kim, Hyosuk ^{[1
]}

Jang, Hochung ^{[1
,2
]}

Cho, Haeun ^{[1
,3
]}

Choi, Jiwon ^{[1
,4
]}

Hwang, Kwang Yeon ^{[3
]}

Choi, Yeonho ^{[4
]}

Kim, Sun Hwa ^{[1
]}

Yang, Yoosoo ^{[1
,2
]}

机构：

[1] Korea Inst Sci & Technol KIST, Biomed Res Div, Ctr Theragnosis, Seoul 02792, South Korea

[2] Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea

[3] Korea Univ, Dept Biotechnol, Coll Life Sci & Biotechnol, Seoul 02841, South Korea

[4] Korea Univ, Dept Bioengn, 145 Anam Ro, Seoul 02841, South Korea

来源：

CANCERS | 2021年 / 13卷 / 17期

关键词：

exosome; drug delivery system; cancer therapy; exosome engineering; CELL-DERIVED EXOSOMES; MESENCHYMAL STEM-CELLS; SMALL-INTERFERING RNA; NEONATAL FC-RECEPTOR; INHIBIT IN-VITRO; EXTRACELLULAR VESICLES; DENDRITIC CELLS; MILK EXOSOMES; SIRNA DELIVERY; NANO-CARRIERS;

D O I：

10.3390/cancers13174435

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Simple Summary Exosomes derived from various sources can deliver therapeutic agents such as small molecule drugs, nucleic acids, and proteins to cancer cells by passive or active targeting. These exosomes can encapsulate drugs inside the exosomes, extending drug half-life and increasing drug release stability. In addition, exosomes are highly biocompatible due to their endogenous origin and can be used as nanocarriers for tissue-specific targeted delivery. This review discusses recent advances in exosome-based drug delivery for cancer therapy. Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocompatibility and low immunogenicity for efficient delivery of therapeutic agents such as chemotherapeutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of exosome-based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.

引用

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