Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches

被引：241

作者：

Tan, Li-Li ^{[1
]}

Li, Haiwei ^{[2
]}

Qiu, Yu-Chen ^{[1
]}

Chen, Dai-Xiong ^{[1
]}

Wang, Xin ^{[1
]}

Pan, Rui-Yi ^{[1
]}

Wang, Yan ^{[1
]}

Zhang, Sean Xiao-An ^{[1
]}

Wang, Bo ^{[2
]}

Yang, Ying-Wei ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, Int Joint Res Lab Nanomicro Architecture Chem NMA, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China

[2] Beijing Inst Technol, China Sch Chem, Key Lab Cluster Sci, Minist Educ, Beijing 100081, Peoples R China

来源：

CHEMICAL SCIENCE | 2015年 / 6卷 / 03期

基金：

美国国家科学基金会; 中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

MESOPOROUS SILICA NANOPARTICLES; TRANSMEMBRANE TRANSPORT; MOLECULAR RECOGNITION; CONTROLLED-RELEASE; IN-VITRO; WATER; CAPTURE; ENHANCEMENT; POLYMERS; HYDROGEN;

D O I：

10.1039/c4sc03749a

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

引用

收藏

页码：1640 / 1644

页数：5

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