Synthesis of new series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones for their bacterial and cyclin-dependent kinases (CDKs) inhibitory activities

被引：25

作者：

Geffken, Detlef ^{[2
]}

Soliman, Raafat ^{[1
]}

Soliman, Farid S. G. ^{[1
]}

Abdel-Khalek, Magdi M. ^{[1
]}

Issa, Doaa A. E. ^{[1
]}

机构：

[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut Chem, Alexandria, Egypt

[2] Univ Hamburg, Dept Pharmaceut Chem, Inst Pharm, Hamburg, Germany

来源：

MEDICINAL CHEMISTRY RESEARCH | 2011年 / 20卷 / 04期

关键词：

Pyrazole; Pyrazolo[4,3-d]pyrimidin-7-one; Pyrido[2,3-d]pyrimidin-4-one; Hydrazono-pyridazine; Antibacterial activity; ANTIBACTERIAL ACTIVITY; SILDENAFIL ANALOGS; PHENYL RING; DERIVATIVES; ACID; OLOMOUCINE; POTENT; MOIETY; CDC2;

D O I：

10.1007/s00044-010-9328-z

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Two series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones were designed, synthesised, and evaluated for their antibacterial activities and CDKs inhibitory activities. The pyridazine derivative: 6-phenyl-5-phenylhydrazono-2,3,4,5-tetrahydropyridazine-3,4-dione (3a) revealed activity against Staphylococcus aureus as Gram-positive bacteria while compound 2-(2-Ethoxyphenyl-5-Phenylpiperazinosulfonamido)-3H-pyrido[2,3-d]pyrimidin-4-one (13c) was showing moderate antifungal activity against Candida albicans.

引用

页码：408 / 420

页数：13

共 33 条

[1]

DEVELOPMENT OF ETHYL 3,4-DIHYDRO-4-OXOPYRIMIDO[4,5-B]QUINOLINE-2-CARBOXYLATE, A NEW PROTOTYPE WITH ORAL ANTIALLERGY ACTIVITY [J].