GPCR deorphanizations: the novel, the known and the unexpected transmitters

被引：94

作者：

Civelli, O ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA

[2] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 01期

关键词：

D O I：

10.1016/j.tips.2004.11.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pairing orphan G-protein-coupled receptors (GPCRs) to potential ligands found in tissue extracts or in libraries of synthetic compounds has identified an ever-increasing number of transmitters, some of which are novel, some of which were previously known and, more recently, some of which are unexpected. These discoveries raise questions about the nature of transmitters and the specificity of GPCRs. In this article, several aspects of the impact of orphan GPCR research on our understanding of the diversity of transmitters will be discussed.

引用

页码：15 / 19

页数：5

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