Signal transduction pathways leading to cell cycle arrest and apoptosis induced by DNA topoisomerase poisons

被引：12

作者：

Andoh, T ^{[1
]}

机构：

[1] Soka Univ, Fac Engn, Hachioji, Tokyo 1920003, Japan

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2000年 / 33卷 / 02期

关键词：

signal transduction; cell cycle checkpoint; apoptosis; topoisomerase; p53; JNK; p38; ATM; DNA-PK; ASK1;

D O I：

10.1385/CBB:33:2:181

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this overview, I have summarized the important pathways of stress-induced signal transduction: stabilization and activation of p53 playing a central role in stress-induced cell cycle checkpoint and apoptosis, and activation of ASK1-JNK/p38 pathway often induced by a variety of stress stimuli, which appears to be essentially required for apoptosis to follow.

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页码：181 / 188

页数：8

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