Increased serum S-100B and neuron specific enolase - Potential markers of early nervous system involvement in essential hypertension

被引：25

作者：

Gonzalez-Quevedo, Alina ^{[1
]}

Gonzalez Garcia, Sergio ^{[1
]}

Fernandez Concepcion, Otman ^{[1
]}

Santiesteban Freixas, Rosaralis ^{[1
]}

Quevedo Sotolongo, Luis ^{[2
]}

Caridad Menendez, Maria ^{[1
]}

Pena Sanchez, Marisol ^{[1
]}

Fernandez Almirall, Isabel ^{[1
]}

Fernandez Carriera, Rebeca ^{[1
]}

Hernandez Diaz, Zenaida ^{[1
]}

Menendez, Keiny ^{[1
]}

机构：

[1] Inst Neurol & Neurosurg, Havana 10400, Cuba

[2] Cira Garcia Cent Clin, Havana, Cuba

来源：

CLINICAL BIOCHEMISTRY | 2011年 / 44卷 / 2-3期

关键词：

Hypertension; Neuron specific enolase; S-100B; Cerebrovascular disease; Retinopathy; Magnetic resonance imaging (MRI); CEREBRAL-BLOOD-FLOW; BRAIN-DAMAGE; ISCHEMIC-STROKE; DISORDERS; BIOMARKER; INJURY; S100B; RISK; NSE;

D O I：

10.1016/j.clinbiochem.2010.11.006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Objectives: To investigate the occurrence of subclinical neurologic involvement in patients with essential hypertension employing serum biochemical markers. Design and methods: Fifty patients with essential hypertension and 42 controls with no clinical evidence of neurological disease were recruited. Serum S100B protein and neuron specific enolase (NSE) were determined by employing immunoassay kits from CanAg Diagnostics AB (Sweden). Brain MRI and fundoscopic exploration were conducted. Results: S-100B and NSE levels were significantly higher in hypertensive patients than in controls. In hypertensive patients, multivariate analysis revealed that NSE was independently associated with two variables expressing severity of hypertension: diastolic blood pressure and grade of retinopathy. Brain MRI studies demonstrated higher NSE levels in patients with more severe white matter lesions. Conclusions: Raised NSE levels are associated with a higher severity of hypertension and of white matter lesions, providing preliminary evidence that suggests the presence of silent brain damage in a subset of hypertensive patients. (C) 2010 The Canadian society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：154 / 159

页数：6

共 30 条

[1]

Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients [J].