Tight junctions: from simple barriers to multifunctional molecular gates

被引：1304

作者：

Zihni, Ceniz ^{[1
]}

Mills, Clare ^{[1
]}

Matter, Karl ^{[1
]}

Balda, Maria S. ^{[1
]}

机构：

[1] UCL, UCL Inst Ophthalmol, Dept Cell Biol, Bath St, London EC1V 9EL, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2016年 / 17卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

NUCLEOTIDE EXCHANGE FACTOR; TRANSEPITHELIAL ELECTRICAL-RESISTANCE; PARACELLULAR CHLORIDE PERMEABILITY; TRANSCRIPTION FACTOR ZONAB/DBPA; TUBE SIZE CONTROL; EPITHELIAL-CELLS; ADHESION MOLECULE; PROTEIN ZO-1; CLAUDIN-2; EXPRESSION; ZONULA OCCLUDENS;

D O I：

10.1038/nrm.2016.80

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Epithelia and endothelia separate different tissue compartments and protect multicellular organisms from the outside world. This requires the formation of tight junctions, selective gates that control paracellular diffusion of ions and solutes. Tight junctions also form the border between the apical and basolateral plasma-membrane domains and are linked to the machinery that controls apicobasal polarization. Additionally, signalling networks that guide diverse cell behaviours and functions are connected to tight junctions, transmitting information to and from the cytoskeleton, nucleus and different cell adhesion complexes. Recent advances have broadened our understanding of the molecular architecture and cellular functions of tight junctions.

引用

页码：564 / 580

页数：17

共 180 条

[1]

Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein [J].