AMP-Activated protein kinase: A key stress signaling pathway in the heart

被引：138

作者：

Young, LH ^{[1
]}

Li, J ^{[1
]}

Baron, SJ ^{[1
]}

Russell, RR ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Sect Cardiovasc Med, New Haven, CT 06510 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.tcm.2005.04.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AMP-activated protein kinase (AMPK) is activated during exercise and ischemia and is emerging as an important regulatory mechanism in the heart. AMPK promotes adenosine triphosphate-generating pathways, including glucose transport, glycolysis, and fatty acid oxidation, while inhibiting energy-consuming anabolic pathways. After ischemia-reperfusion, AMPK-deficient hearts from transgenic mice have severe left ventricular contractile dysfunction with increased apoptosis and necrosis. Mutations in the AMPK gamma(2) subunit lead to cardiac glycogen overload, Wolff-Parkinson-White syndrome, arrhythmias, and heart failure. This review focuses on the molecular mechanisms of activation and cardiovascular actions of AMPK in the heart.

引用

页码：110 / 118

页数：9

共 89 条

[41]

Kemp BE, 2003, BIOCHEM SOC T, V31, P162

[42] Bateman domains and adenosine derivatives form a binding contract [J].

Kemp, BE .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (02) :182-184

[43] A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway [J].

Kimura, N ;

Tokunaga, C ;

Dalal, S ;

Richardson, C ;

Yoshino, K ;

Hara, K ;

Kemp, BE ;

Witters, LA ;

Mimura, O ;

Yonezawa, K .

GENES TO CELLS, 2003, 8 (01) :65-79

[44] Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart [J].

Kovacic, S ;

Soltys, CLM ;

Barr, AJ ;

Shiojima, I ;

Walsh, K ;

Dyck, JRB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (41) :39422-39427

[45] HIGH-RATES OF FATTY-ACID OXIDATION DURING REPERFUSION OF ISCHEMIC HEARTS ARE ASSOCIATED WITH A DECREASE IN MALONYL-COA LEVELS DUE TO AN INCREASE IN 5'-AMP-ACTIVATED PROTEIN-KINASE INHIBITION OF ACETYL-COA CARBOXYLASE [J].

KUDO, N ;

BARR, AJ ;

BARR, RL ;

DESAI, S ;

LOPASCHUK, GD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (29) :17513-17520

[46] Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia [J].

Kudo, N ;

Gillespie, JG ;

Kung, L ;

Witters, LA ;

Schulz, R ;

Clanachan, AS ;

Lopaschuk, GD .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1996, 1301 (1-2) :67-75

[47] RETRACTED: AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells (Retracted article. See vol. 293, pg. 18013, 2018) [J].

Lee, M ;

Hwang, JT ;

Lee, HJ ;

Jung, SN ;

Kang, IS ;

Chi, SG ;

Kim, SS ;

Ha, JH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (41) :39653-39661

[48] Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle [J].

Li, J ;

Hu, XY ;

Selvakumar, P ;

Russell, RR ;

Cushman, SW ;

Holman, GD ;

Young, LH .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2004, 287 (05) :E834-E841

[49] Constitutively active adenosine monophosphate - Activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes [J].

Light, PE ;

Wallace, CHR ;

Dyck, JRB .

CIRCULATION, 2003, 107 (15) :1962-1965

[50] LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 [J].

Lizcano, JM ;

Göransson, O ;

Toth, R ;

Deak, M ;

Morrice, NA ;

Boudeau, J ;

Hawley, SA ;

Udd, L ;

Mäkelä, TP ;

Hardie, DG ;

Alessi, DR .

EMBO JOURNAL, 2004, 23 (04) :833-843

← 1 2 3 4 5 6 7 8 9 →