Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification

被引：34

作者：

Gadd, Morgan S. ^{[1
]}

Bhati, Mugdha ^{[1
]}

Jeffries, Cy M. ^{[1
]}

Langley, David B. ^{[1
]}

Trewhella, Jill ^{[1
]}

Guss, J. Mitchell ^{[1
]}

Matthews, Jacqueline M. ^{[1
]}

机构：

[1] Univ Sydney, Sch Mol Biosci, Sydney, NSW 2006, Australia

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 50期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

ANGLE SCATTERING DATA; MOTOR-NEURON; MACROMOLECULAR STRUCTURES; INTERNEURON IDENTITY; LMO4-LDB1; COMPLEX; LHX3; CRYSTALLIZATION; PROGRAM; DOMAINS; BINDING;

D O I：

10.1074/jbc.M111.248559

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Lhx and Isl proteins contribute to genetic control in developing neurons. Results: The Lhx3/4-binding motif in Isl2 was identified, and the structures of Lhx-Isl complexes were characterized and compared. Conclusion: There are minor differences in the structures of Lhx3/4 binding Isl1/2 reflected by mutational and biophysical analyses. Significance: Redundant sets of interactions conserve function in developing neurons while allowing divergence in other contexts.

引用

页码：42971 / 42980

页数：10

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