Antifreeze glycoproteins: Elucidation of the structural motifs that are essential for antifreeze activity

被引：184

作者：

Tachibana, Y

Fletcher, GL

Fujitani, N

Tsuda, S

Monde, K

Nishimura, SI ^{[1
]}

机构：

[1] Hokkaido Univ, Frontier Res Ctr Postgenom Sci & Technol, Grad Sch Sci, Div Biol Sci, Sapporo, Hokkaido 0010021, Japan

[2] Mem Univ Newfoundland, Ctr Ocean Sci, St Johns, NF A1C 5S7, Canada

[3] Natl Inst Adv Ind Sci & Technol, Struct Biol Grp, Sapporo, Hokkaido 0628517, Japan

[4] Natl Inst Adv Ind Sci & Technol, Res Ctr Glycosci, Glycochemosynth Team, Sapporo, Hokkaido 0628517, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 07期

关键词：

carbohydrates; computer chemistry; glycopeptides; glycoproteins;

D O I：

10.1002/anie.200353110

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Good for winter: The structure-activity relationships of antifreeze glycoproteins (AFGPs) have been characterized by chemical synthesis and conformational analysis. The results revealed that the mode of glycosylation on the threonyl residue in the tripeptide unit is of primary importance in the formation of the specific structure for the antifreeze activity (see picture for the structural requirements of AFGPs).

引用

页码：856 / 862

页数：7

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