RECEPTORS GPCR-G protein preassembly?

被引：7

作者：

Challiss, R. A. John ^{[1
]}

Wess, Juergen ^{[2
]}

机构：

[1] Univ Leicester, Dept Cell Physiol & Pharmacol, Coll Med Biol Sci & Psychol, Leicester LE1 9HN, Leics, England

[2] NIDDK, Mol Signaling Sect, Bioorgan Chem Lab, NIH, Bethesda, MD USA

来源：

NATURE CHEMICAL BIOLOGY | 2011年 / 7卷 / 10期

关键词：

COUPLED RECEPTORS; LIVING CELLS; COMPLEXES;

D O I：

10.1038/nchembio.665

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The extent to which ligand-free GPCRs exist in quasi-stable 'precoupled' complexes with G proteins in vivo is uncertain. New research, using fluorescence recovery after photobleaching (FRAP), reveals a structural requirement for and functional consequences of muscarinic acetylcholine receptor–Gq protein preassembly.

引用

页码：657 / 658

页数：2

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