Eosinophils: Biological properties and role in health and disease

被引：615

作者：

Hogan, Simon P.

Rosenberg, Helene F.

Moqbel, Redwan

Phipps, Simon

Foster, Paul S.

Lacy, Paige

Kay, A. Barry

Rothenberg, Marc E.

机构：

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2008年 / 38卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1111/j.1365-2222.2008.02958.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of diverse inflammatory responses, as well as modulators of innate and adaptive immunity. In this review, the biology of eosinophils is summarized, focusing on transcriptional regulation of eosinophil differentiation, characterization of the growing properties of eosinophil granule proteins, surface proteins and pleiotropic mediators, and molecular mechanisms of eosinophil degranulation. New views on the role of eosinophils in homeostatic function are examined, including developmental biology and innate and adaptive immunity (as well as their interaction with mast cells and T cells) and their proposed role in disease processes including infections, asthma, and gastrointestinal disorders. Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized.

引用

页码：709 / 750

页数：42

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