The use of hydrogel for biomaterials or as 3D synthetic matrix for tissue engineering lead to determine the viscoelastic properties of the hydrogels and the moment when the viscous liquid is transformed in a reticulated polymer network. This can be performed by oscillatory rheological study. We developed a new self-reticulating polymer wich is silated hydroxyl propylmethylcellulosc (Si-BPMC). This study shows that the parameters (pH, swelling, amount of silane grafting) can be controlled and adjusted using oscillatory rheological measurements. The polymer network can be adapted to provide the best environment for specific cell functions and use it as a scaffold for tissue engineering and as injectable biomaterial for bone repair.