Regulatory circuits of T cell function in cancer

被引：511

作者：

Speiser, Daniel E. ^{[1
,2
]}

Ho, Ping-Chih ^{[1
]}

Verdeil, Gregory ^{[1
]}

机构：

[1] Univ Lausanne, Dept Oncol, Ludwig Canc Res, Biopole 3 02DB92,Chemin Boveresses 155, CH-1066 Epalinges, Switzerland

[2] Princess Margaret Canc Ctr, Campbell Family Inst Breast Canc Res, Ontario Canc Inst, 610 Univ Ave, Toronto, ON M5G 2M9, Canada

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

TUMOR-ASSOCIATED MACROPHAGES; LARGE ESTABLISHED TUMORS; ANTITUMOR-ACTIVITY; SUPPRESSOR-CELLS; IMMUNE PRIVILEGE; DENDRITIC CELLS; EMERGING ROLE; MEMORY; EFFECTOR; PROMOTES;

D O I：

10.1038/nri.2016.80

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Recent progress in cancer immunotherapy emphasizes the importance of understanding immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to mechanisms that are evolutionarily conserved or acquired by somatic mutations. The dysfunctional state of T cells has been termed 'exhaustion', on the basis of similarities to dysfunctional T cells in chronic infections. However, despite shared properties, recent studies have identified marked differences between T cell dysfunction in cancer and chronic infection. In this Review, we discuss T cell-intrinsic molecular alterations and metabolic communication in the tumour microenvironment. Identification of the underlying molecular drivers of T cell dysfunction is essential for the continued progress of cancer research and therapy.

引用

页码：500 / 611

页数：13

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