Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema

被引：182

作者：

Ishizawa, K

Kubo, H ^{[1
]}

Yamada, M

Kobayashi, S

Numasaki, M

Ueda, S

Suzuki, T

Sasaki, H

机构：

[1] Tohoku Univ, Sch Med, Dept Geriatr & Resp Med, Sendai, Miyagi 9808574, Japan

[2] Miyagi Canc Ctr, Natori, Miyagi 9891239, Japan

[3] Tohoku Univ, Sch Med, Dept Pathol, Sendai, Miyagi 9808574, Japan

来源：

FEBS LETTERS | 2004年 / 556卷 / 1-3期

基金：

日本学术振兴会;

关键词：

bone marrow; progenitor cell; pulmonary emphysema; granulocyte colony-stimulating factor; regeneration;

D O I：

10.1016/S0014-5793(03)01399-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All-trans retinoic acid (ATRA) is known to reverse the anatomic and physiologic signs of pulmonary emphysema. However, the origin of the progenitor cells involved in this lung regeneration remains unclear. Recently, it was shown that bone marrow could be the source of progenitor cells for several cell types. Mice with elastase-induced emphysema were treated with ATRA, granulocyte colony-stimulating factor (G-CSF), or a combination of both. ATRA or G-CSF promoted lung regeneration and increased bone marrow-derived cell (BMC) numbers in alveoli. Combined treatment of both had an additive effect, which indicated that BMC mobilization might be important in lung regeneration. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：249 / 252

页数：4

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