Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid

被引：11

作者：

Dankwardt, SM

Phan, TM

Krstenansky, JL

机构：

[1] Syntex Discovery Research, Chemical Research and Development, Palo Alto, 94304, CA

来源：

MOLECULAR DIVERSITY | 1996年 / 1卷 / 02期

关键词：

solid-phase synthesis; combinatorial approach; non-peptide library; 3-amino-5-hydroxybenzoic acid;

D O I：

10.1007/BF01721326

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A non-peptide library of 2001 compounds has been prepared utilizing solid-phase techniques. The split/combine method was demonstrated to work well to form mixtures of compounds based on 3-amino-5-hydroxybenzoic acid as a core structure. The benzoic acid of the core structure served as the attachment point for the resin and the amino and hydroxy positions were variably substituted.

引用

页码：113 / 120

页数：8

共 26 条

[21] SOLID-PHASE SYNTHESIS OF PROTECTED PEPTIDE-FRAGMENTS USING A TRIALKOXY-DIPHENYL-METHYLESTER RESIN [J].