Coding and noncoding genomic regions of Entamoeba histolytica have significantly different rates of sequence polymorphisms:: Implications for epidemiological studies

被引：23

作者：

Bhattacharya, D

Haque, R

Singh, U

机构：

[1] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Internal Med, Div Infect Dis, Stanford, CA 94305 USA

[3] Int Ctr Diarrhoeal Dis Res, Ctr Hlth & Populat Res, Dhaka 1000, Bangladesh

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 09期

关键词：

D O I：

10.1128/JCM.43.9.4815-4819.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To evaluate genetic variability among Entamoeba histolytica strains, we sequenced 9,077 bp from each of 14 isolates. The polymorphism rates from coding and noncoding regions were significantly different (0.07% and 0.37%, respectively), indicating that these regions are subject to different selection pressures. Additionally, single nucleotide polymorphisms (SNPs) potentially associated with specific clinical outcomes were identified.

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页码：4815 / 4819

页数：5

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