Implementation of Raman spectroscopy as an analytical tool throughout the synthesis of solid-phase scaffolds

被引：16

作者：

Pivonka, DE ^{[1
]}

Sparks, RB ^{[1
]}

机构：

[1] AstraZeneca Pharmaceut, Wilmington, DE 19850 USA

来源：

APPLIED SPECTROSCOPY | 2000年 / 54卷 / 11期

关键词：

Raman spectroscopy; on-line analysis; combinatorial chemistry;

D O I：

10.1366/0003702001948835

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Raman spectroscopy has been implemented as an extremely powerful tool for the vibrational analysis of solid-phase synthesis. In this report, the application of both on-line and batch-mode Raman analysis is presented for the comprehensive characterization of a multi-step small-molecule synthesis. Throughout this application, near-infrared Raman spectroscopy also provides unprecedented utility for on-bead qualitative and quantitative investigations. Finally, the on-line experimental procedure presents the first opportunity for open-loop feedback control of solid-phase synthetic parameters through the real-time presentation of reaction progression using Raman spectroscopy.

引用

页码：1584 / 1590

页数：7

共 15 条

[1] High throughput on-bead monitoring of solid phase reactions by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) [J].