A chemical approach to stem cell biology

被引：42

作者：

Emre, Nil

Coleman, Ronald

Ding, Sheng

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2007年 / 11卷 / 03期

关键词：

D O I：

10.1016/j.cbpa.2007.04.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small molecule libraries have been used successfully to probe several biological systems. Recent work has translated these successes across to the field of stem cell biology. Stem cells hold promise for both modeling of early development as well as having therapeutic potential. Enhanced understanding of the molecular mechanisms that control stem cell fates as well as an improved ability to manipulate cell populations are required. Known mechanistic chemical compounds have been used with stem cells to accomplish these two goals. More recently, through the utilization of high fitness libraries in phenotype-based screens, several small molecules that control self-renewal and differentiation in stem cells have been identified. These small molecules provide useful chemical tools for both basic research and practical applications.

引用

收藏

页码：252 / 258

页数：7

相关论文

共 63 条

[1] Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle [J].

Anastasia, Luigi ;

Sampaolesi, Maurilio ;

Papini, Nadia ;

Oleari, Diego ;

Lamorte, Giuseppe ;

Tringali, Cristina ;

Monti, Eugenio ;

Galli, Daniela ;

Tettamanti, Guido ;

Cossu, Giulio ;

Venerando, Bruno .

CELL DEATH AND DIFFERENTIATION, 2006, 13 (12) :2042-2051

[2]

Androutsellis-Theotokis A, 2006, NATURE, V442, P823, DOI 10.1038/nature04940

[3] The Src family of tyrosine kinases is important for embryonic stem cell self-renewal [J].

Annerén, C ;

Cowan, CA ;

Melton, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (30) :31590-31598

[4] The regulation of self-renewal in human embryonic stem cells [J].

Avery, Stuart ;

Inniss, Katie ;

Moore, Harry .

STEM CELLS AND DEVELOPMENT, 2006, 15 (05) :729-740

[5] Chemical library synthesis using convergent approaches [J].

Beeler, AB ;

Schaus, SE ;

Porco, JA .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (03) :277-284

[6] Signalling, cell cycle and pluripotency in embryonic stem cells [J].

Burdon, T ;

Smith, A ;

Savatier, P .

TRENDS IN CELL BIOLOGY, 2002, 12 (09) :432-438

[7] Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells [J].

Burdon, T ;

Stracey, C ;

Chambers, I ;

Nichols, J ;

Smith, A .

DEVELOPMENTAL BIOLOGY, 1999, 210 (01) :30-43

[8] A planning strategy for diversity-oriented synthesis [J].

Burke, MD ;

Schreiber, SL .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (01) :46-58

[9] LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism [J].

Cartwright, P ;

McLean, C ;

Sheppard, A ;

Rivett, D ;

Jones, K ;

Dalton, S .

DEVELOPMENT, 2005, 132 (05) :885-896

[10] Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened [J].

Chen, JK ;

Taipale, J ;

Cooper, MK ;

Beachy, PA .

GENES & DEVELOPMENT, 2002, 16 (21) :2743-2748

← 1 2 3 4 5 6 7 →