Synthesis of mixed acyclic imides using pentafluorophenyl esters

被引：40

作者：

Andrus, MB ^{[1
]}

Li, W

Keyes, RF

机构：

[1] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

[2] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(98)01112-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mixed acyclic imides are assembled using amide anions and pentafluorophenyl esters reacted in THF at low temperature. Sodium hexamethyldisilazide deprotonates lactam 4 followed by addition of pentafluorophenyl (PFP) esters to give imides in high yield(85-90%). Acyclic TMS-protected primary amides were also reacted under basic conditions with PFP esters to give mixed imides. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5465 / 5468

页数：4

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