Highly diastereoselective reactions of 2-lithiated indoles with chiral N-tert-butanesulfinyl aldimines for the synthesis of chiral (2-indolyl) methanamine derivatives

被引：24

作者：

Cheng, Liang

Liu, Li ^{[1
]}

Sui, Yong

Wang, Dong

Chen, Yong-Jun

机构：

[1] Chinese Acad Sci, Inst Chem, Biol Chem Lab, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 15期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.tetasy.2007.07.029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Nucleophilic addition reactions of 2-lithiated N-phenylsulfonylindoles with (R)-N-tert-butanesulfinyl aldimines provided chiral (2-indolyl) methanamine derivatives in moderate to good yields (up to 100%) with excellent diastereoselectivities (>99: 1), in which no additional Lewis acids were required. (C) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1833 / 1843

页数：11

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